Micronutrients

Milk thistle: Benefits, effect and side effects

A woman with braided hair sits on a blanket in a sunny meadow, reading a book. A picnic basket is beside her, surrounded by trees.

Lisa Ressi, MSc

21.08.20243 Reading time

The milk thistle (Silybum marianum) is one of the most well-known medicinal plants that plays a significant role in natural medicine. It is often recommended, especially for liver and digestive problems. But what effects does milk thistle actually have and are there also side effects? In this article, we examine the different aspects of this fascinating plant.

01

What is milk thistle?

The milk thistle belongs to the daisy family and is mainly located in the Mediterranean. Its characteristic purple-coloured flowers and white-veined leaves make it easily recognisable. In medicine, mainly the active substance complex silymarin derived from the fruits and seeds of the plant is used. This has antioxidant, anti-inflammatory and cell-protecting properties, which are particularly valued in the treatment of liver diseases.

02

Health benefits of milk thistle

Milk thistle is known for its varied effects on the human body. Its main active ingredient, silymarin, has an antioxidant, anti-inflammatory and immunomodulatory effect. But the medicinal plant has much more to offer. In the following, we consider the specific effects on various organs and clinical pictures.

How milk thistle supports liver health

The liver is the central organ of the metabolism and of detoxification. The active substance silymarin, which is contained in milk thistle, has proven to be particularly helpful in studies of inflammation and liver diseases due to its anti-inflammatory effect. Silymarin has been shown to protect the liver, support the immune system and to improve general symptoms and liver function values. Silymarin also promotes protein production, which supports the regeneration of the liver cells.

Benefits of milk thistle on the gallbladder

The milk thistle has a positive effect on the gallbladder. It promotes the formation and drainage of bile, which supports fat digestion and can prevent the formation of gallstones. The milk thistle can offer natural support, especially in people with chronic biliary complaints.

Benefits of milk thistle on the stomach and intestines

The milk thistle is also effective in the digestive tract. It can relieve gastrointestinal symptoms by regulating the production of gastric juices and soothing the inflammatory processes in the intestine. Silymarin also promotes the regeneration of mucous membranes.

03

Pharmaceutical forms of milk thistle: Tea, capsules, etc.

The milk thistle is available in various pharmaceutical forms, depending on individual needs and preference. As tea, it is often used to aid the digestion. Capsules and tablets are an easy way to consume the plant’s concentrated active ingredients, especially to support the liver. Tinctures and powders are also common forms that can be used depending on the application preference.

However, since Silymarin is poorly water-soluble, teas and tinctures are not as effective as high-dose capsules. Capsules can be used to make effective use of the properties of the plant.

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04

Side effects of milk thistle

Persons with an allergy to composite plants should be careful when taking it, as there is an increased risk of allergic reactions. There is insufficient scientific data on the use of milk thistle during pregnancy and on the use in children and it is therefore not recommended.

Lisa Ressi, MSc

Expert in knowledge management & speaker

Lisa Ressi is a certified Health & Care Nurse with a Master's degree in Health Sciences. Her heart has been in micronutrients for over 20 years. During her work as a freelance health and care nurse, she also gained a lot of practical experience with micronutrients. 

Her journey at BIOGENA began in 2014. In addition to her work as a micronutrient consultant at the BIOGENA store in Linz, she has created the Micronutrient Coach® compact course with great commitment and love. She has been a member of the BIOGENA science team since 2022 where she fulfills her great passion for knowledge transfer. True to the motto “Knowledge creates health”, she shares her knowledge in lectures, seminars, podcasts and even contributions in a very practical way with all those who are interested in promoting health and supporting therapy with micronutrients.

FAQs

Frequently asked questions about milk thistle

Further reading:

Camini, F.C. et Costa, D.C. 2020. Silymarin: not just another antioxidant, in: J Basic Clin Physiol Pharmacol. Mar 5; 31(4).

Deak, G. et al. 1990. Immunomodulator effect of silymarin therapy in chronic alcoholic liver diseases. Orv Hetil. 131(24):1291-2.

Deep G, Agarwal R. 2010. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev.;29(3):447‐463.

Gargari, B. et al. (2015). Effects of Silybum marianum (L.) Gaertn.(silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Phytomedicine, 22(2), 290-296.

Gu, J., et al. (2015). An open-label, randomized and multi-center clinical trial to evaluate the efficacy of Silibinin in preventing drug-induced liver injury. International journal of clinical and experimental medicine, 8(3), 4320.

Kim, M.S. et al. 2016. Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination? in: World J Gastroenterol.;22(1):8-23.

Li Volti, et al. 2011. Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice. Cardiovascular diabetology, 10, 1-8.

Malewicz, B., et al. 2006. Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements. Carcinogenesis, 27(9), 1739-1747.

Raina, K., Kumar, S., Dhar, D., & Agarwal, R. 2016. Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy. Journal of biomedical research, 30(6), 452.

Vargas-Mendoza N. et al. 2020. Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications, in: Biomedicines; 8(5), S.122.

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