Skin & Beauty

The gut-skin axis: how gut health and skin are connected

from Mag. Margit Weichselbraun
on 31.03.2025

What do your gut and skin have in common? Quite a lot! Both are densely populated microbiome worlds – and key players in your well-being. Around one trillion microorganisms live in every gram of tissue in your large intestine. And your skin is home to as many microbes as there are people on Earth in just two square metres. Fascinating, isn't it? Even more exciting: the gut and skin are closely connected. Find out how these two systems are linked – and why this is important for you – on our journey through the skin-gut axis.

Your skin? A reflection of your gut

Skin and gut – a well-coordinated duo. What sounds almost romantic can be explained scientifically: both originate from the same embryonic layer (one of the cell layers from which all organs and tissues form in the first weeks of an embryo's development), are among the most surface-rich organs in our body and are densely populated. And they remain closely connected in adult life – via nerves, blood vessels and, above all, the immune system.

What's particularly exciting is that the gut influences the skin – as a growing number of studies show. Although not all the mechanisms have been deciphered yet, the gut flora plays a central role. Your gut flora weighs around two kilograms – and it's got a lot to offer. This is because it is in constant communication with your immune cells and provides important stimuli for the formation of antibodies. This daily interaction is a kind of immune training that has an effect far beyond the gut and can also benefit your skin.

But that's not all: our gut bacteria are true multitaskers – they produce important substances such as biotin and hyaluronic acid, which play a role in skin care from the inside out. They also influence the nervous system – and can thus help regulate blood flow to the skin, for example. Pretty impressive what our microbiome can do, right?

The gut-skin axis: when your inner balance is disrupted – and your skin reacts

‘If your gut isn't healthy, your skin suffers’ – and vice versa. This is because the centre of our body is not only responsible for digestion, but also interacts closely with the skin. If the intestinal environment becomes unbalanced, this can also manifest itself externally via the so-called gut-skin axis.

Studies show that people with skin problems such as blemishes or irritation often have altered gut flora – for example, with fewer lactobacilli or bifidobacteria – as well as a disrupted intestinal barrier. Under additional stress, these imbalances can even worsen.

Studies also show that disrupted gut flora can promote inflammatory skin conditions. This is why people with acne are often affected by altered gut flora. A promising clinical approach to supporting skin health is the targeted modulation of gut flora through oral probiotics (beneficial bacteria).

Our modern lifestyle also makes life difficult for the gut: antibiotics, laxatives and a diet low in vital nutrients reduce microbial diversity. While indigenous peoples still have impressive diversity in their intestines, many people in Western industrialised nations have already lost around 40% of this – with noticeable consequences. Because less diversity also means fewer beneficial substances, limited nutrient utilisation and reduced detoxification. And it is precisely this that the skin feels – as an external reflection of our inner balance.

An imbalance in the microbiome can also lead to an increase in unwanted metabolic products such as free phenols and paracresol, which put strain on the intestinal barrier. At the same time, the production of important skin-relevant substances such as hyaluronic acid, vitamins and antioxidants can decline – or their absorption from food is disrupted. The result: the intestine is out of sync – and your skin shows it.

How gut bacteria, fibre and vitamins support your skin

Do you have blemished skin? Then it's worth looking beyond the surface – or, more precisely, into your gut. Skin problems often run deeper, and your gut plays a bigger role than you think. Our beneficial gut bacteria – especially lactobacilli and bifidobacteria – are real beauty boosters when they get what they love: food that tastes good to them and is good for us.

Fibre & bitter compounds: favourite foods for the skin microbiome

Soluble fibre is a feast for our good gut bacteria. It is found in plant-based foods such as fruit, vegetables, whole grains and legumes. At the top of the list are black salsify, Jerusalem artichokes and parsnips – real superstars for the gut flora.

Bitter substances also play a role: plants such as milk thistle and artichokes stimulate the liver and gallbladder, thereby boosting intestinal activity. And a healthy gut? That is often the first step to beautiful skin.

Vitamins for skin & gut

If the intestine is not functioning properly, it can no longer optimally absorb important nutrients such as vitamins, minerals and trace elements – such as zinc. Both the skin and the intestinal mucosa need nutrients in order to perform their protective function optimally. The most important ones include:

  • Vitamins A, B2, niacin & biotin – help maintain healthy mucous membranes.
  • Vitamin C, vitamin E & biotin – real skin care from within.
    • Biotin supports normal skin.
    • Vitamin C helps form collagen, which is important for healthy connective tissue.
    • Vitamins C & E also help protect cells from oxidative stress, such as that caused by UV rays.
  • Copper and zinc: are involved in numerous regenerative and protective processes. Zinc supports cell renewal and protects cells from oxidative stress, while copper contributes to normal skin pigmentation and the maintenance of connective tissue. Through their combined action, copper and zinc promote resilient and even skin.

In short: taking care of your gut and skin together gives your well-being a real boost – from the inside out.

biogena-line
BIOGENA AESTHETICS Skin Biotic+
High-quality formula with intestinal bacteria - supports your skin with zinc and copper - for an even complexion
To the product
€49.90

Your gut and its bacteria love:

  • soluble fiber from fruits, vegetables, legumes, and whole-wheat products
  • bitter plants like milk thistle and artichokes
  • fermented foods, like sauerkraut
  • for healthy mucus membranes: vitamins A, B2, niacin, biotin
  • sufficient liquids, like water or unsweetened herbal tea
  • choose preparation methods that preserve nutrients (steaming or simmering instead of roasting or frying over high heat)
  • chewing properly
  • eating meals in a peaceful and quiet atmosphere

This is not good for your gut and its bacteria:

  • low fiber
  • lots of sugar
  • lots of unhealthy fats
  • high protein content
  • alcohol
  • food additives (found in highly processed foods like ready meals, prepared sauces, etc.)
  • certain medications (antibiotics, laxatives, contraceptives, hormone supplements, etc.)

Happy intestinal flora, happy skin

Conclusion – happy gut flora, happy skin

A healthy gut does more than just aid digestion – it can also have a positive effect on your skin. This is because balanced gut flora not only supports your gut feeling, but also your complexion. So if you want to harness the beauty power of your gut bacteria, you should give them what they need: good care, nutrient-rich food and a little attention.

Frequently asked questions about the gut and skin microbiome

The gut-skin axis describes the close connection between the intestinal flora and skin health. Studies show that an imbalance in the intestinal flora (dysbiosis) can not only cause intestinal problems, but also promote inflammatory skin diseases such as acne and rosacea. Skin problems such as blemishes, redness, dryness or itching can also be linked to an imbalance in the intestinal flora.

Yes, intestinal problems can contribute to skin problems – for example, through a disturbed microbiome or a weakened intestinal barrier, which can have a negative effect on the appearance of the skin.

Sources

Quellen:Gao, T. et al. 2023. The Role of Probiotics in Skin Health and Related Gut–Skin Axis: A Review. Nutrients.15(14):3123. https://pubmed.ncbi.nlm.nih.gov/37513540/

Sticherling M. 2020. Mit Probiotika lässt die Darm-Haut-Achse positiv beeinflussen. Kompass Autoimmun 2020; 2:106-107.

Szántó, M. et al. 2019. Targeting the gut-skin axis—Probiotics as new tools for skin disorder management? Exp Dermatol. 28(11):1210–8. https://pubmed.ncbi.nlm.nih.gov/31386766/

Nam, J.-H. et al. 2018. Rosacea and its association with enteral microbiota in Korean females. Exp Dermatol. 27(1):37–42. https://pubmed.ncbi.nlm.nih.gov/28636759/

Polkowska-Pruszyńska B. Gerkowicz  A. Krasowska D, 2020. The gut microbiome alterations in allergic and inflammatory skin diseases - an update. J Eur Acad Dermatol Venereol. 2020 Mar;34(3):455-464 https://pubmed.ncbi.nlm.nih.gov/31520544/

Lee SY, 2018. Microbiome in the Gut-Skin Axis in Atopic Dermatitis. Allergy Asthma Immunol Res. 2018 Jul;10(4):354-362. https://pubmed.ncbi.nlm.nih.gov/29949831/

O’Neill CAO, 2016. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. 2016 Nov;38(11):1167-1176. https://pubmed.ncbi.nlm.nih.gov/27554239/

Sinha S. et al. 2021. The skin microbiome and the gut-skin axis. Clin Dermatol. 2021 Sep-Oct;39(5):829-839. https://pubmed.ncbi.nlm.nih.gov/34785010/

Bowe, W. P., Logan, A. C. 2011. Acne vulgaris, probiotics and the gut-brain-skin axis—back to the future? Gut Pathog. 3(1):1. https://pubmed.ncbi.nlm.nih.gov/21281494/

Yan, H. M. et al. 2018. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018 Oct;45(10):1166-1171 https://pubmed.ncbi.nlm.nih.gov/30101990/

Salem, I. et al. 2018. The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol. 10:9:1459. https://pubmed.ncbi.nlm.nih.gov/30042740/ 

More articles
The gut-brain axis
Much of our emotional and intellectual experiences are located at waist-level: evidence of the delicate and yet palpable link between the belly and the brain. This mind-midriff connection is hardly surprising; after all, the human brain and gut are...
Gut remediation: from bowel cleansing to bowel reconstruction
Gut remediation: from bowel cleansing to bowel reconstruction
Do you also want to reboot your body physically? Perhaps this is because of a period of doing nothing, a New Year’s resolution, a promise for Lent or just a spontaneous decision. What could be better than restoring the status quo of your no. 1...
Woman with black hair and smooth skin with her hands on her head
‘Vegan collagen’ – the plant-based alternative and its effect
Collagen supplements are considered the key to firm skin, but they are obtained from animal sources – a clear contradiction to vegan and animal-friendly principles. But what if there were a plant-based or vegetarian alternative that was just as...