Creatine is very popular with ambitious athletes. The white powder is said to boost performance, especially in high-intensity sprint, interval and strength sports, and thus become a possible game-changer. But creatine is also trending when it comes to longevity. Here you can learn more about the vital and fuel and what to consider when taking it.
Creatine (from the Greek kreas, meaning ‘meat’) is an organic acid and a real energy booster for our body. Every day, our liver, kidneys and pancreas produce around 1 to 2 grams of it – with the help of the amino acids arginine, glycine and methionine. Kreatin enters the target tissue via the bloodstream, especially the skeletal muscles: around 90 per cent of the stores are located here. But the heart, brain, nervous system and sperm are also ‘kreatin-loaded’.
You can't do it without creatine! That's because creatine is involved in the provision of energy that is immediately available to the muscles when they need it straight away during short, explosive or interval-style exertions.
To understand the exact role of creatine in the energy supply, one should also be familiar with ATP. Adenosine triphosphate (ATP) is a high-energy compound that releases energy when a phosphate group is split off and becomes adenosine diphosphate (ADP). Our bodies constantly draw on their ATP reserves during fast, powerful exertions. However, these reserves are small and depleted after just a few seconds.
This is where creatine comes into play. In the form of creatine phosphate, the energy bundle passes its phosphate group to ADP, thereby recharging the ATP stores. Optimally filled creatine stores help us to breathe longer and allow us to withstand high-intensity stress for longer.
Creatine is one of the most widely researched sports supplements in the world. People with certain pre-existing conditions, such as kidney disease, diabetes or high blood pressure, should take creatine with caution and discuss any planned intake with their doctor in advance.
Creatine is no longer an insider tip among athletes. Athletes benefit from taking creatine in several ways:
Although the brain only makes up about 2% of our body weight, it can consume up to 20% of the body's energy. Like our muscles, the brain, nerves and sensory cells also need the energy source creatine to function and perform.
Although research in this area is less advanced than on the muscular level, the initial study results speak for themselves. For example, targeted creatine supplementation of 5 g per day has positive effects on intelligence and memory performance, mental stress tolerance and cognitive brain functions under stressful conditions. Further studies show that the vital substance can also alleviate some of the symptoms and signs of depression.
Research is also currently being conducted into the use of creatine in neurodegenerative diseases such as Alzheimer's and Parkinson's. Animal studies suggest that a targeted intake could counteract the development of these diseases. However, human studies are still pending in this regard.
What inspires athletes in a sporting sense could also be beneficial for our twilight years, according to longevity research. Studies have shown that the creatine content in our cells declines with increasing age. This development is also associated with a decline in muscle strength and general performance. Meanwhile, several clinical studies show that creatine supplementation in combination with exercise in old age strengthens muscles and bones and reduces the risk of falls.
Older people also benefit mentally from well-filled creatine stores. Various studies show that creatine can help older people to learn better, become more attentive and improve their spatial, mathematical and linguistic memory.
In healthy adults, a creatine intake of 3–5 g per day is considered safe and well tolerated. Side effects, which include gastrointestinal complaints and muscle cramps, occur only rarely, especially at higher dosages. Since creatine increases the water content of muscle cells, it is also possible to gain 1–2 kg in weight. However, this is even desirable in some sports.
People with kidney disease or an increased risk of developing kidney problems (e.g. diabetics, hypertensive patients) should discuss taking creatine with their doctor in advance.
According to estimates, the daily requirement of creatine is about 2 g. Creatine is found in larger quantities in meat and fish. However, since our body has the ability to synthesise the vital substance itself, a minimum supply is usually available even for vegetarians. However, there is a difference between a minimum supply and an optimal supply. The latter can not only strengthen our physical and mental performance, but also our well-being.
The following people should pay particular attention to their creatine levels:
A creatine deficiency can lead to a variety of symptoms, including:
Creatine is not only found in our muscles, but also in those of animals. Accordingly, excellent sources of creatine include various types of meat as well as saltwater and freshwater fish. Milk and dairy products also contain creatine, although only in relatively small amounts. By contrast, fruit and vegetables play no role in the creatine supply. They contain only traces of the substance.
| Food | Approximate creatine content per 100 g |
| Herring | 650 - 1000 mg |
| Pork | 500 mg |
| Beef | 450 mg |
| Salmon | 450 mg |
| Tuna | 400 mg |
| Chicken | 350 - 400 mg |
| Codfish | 300 mg |
| Plaiec | 200 mg |
| Milk | 10 mg |
The optimal creatine dosage can vary depending on your individual needs and training goals. However, between 3 and 5 grams of creatine per day is usually recommended to maximise the body's own creatine stores.
Creatine is available on the market in a variety of formats, including powders, tablets, capsules and bars. It is particularly easy to take in larger amounts of creatine in powder form. With capsules and tablets, several pieces are usually needed to reach the recommended daily amount of 3 to 5 g.
Ultimately, the form in which creatine is administered has no effect on its effectiveness. Rather, consumers should pay attention to the purity and quality of the product. Ideally, you should take supplements from reputable manufacturers that contain 100% pure creatine monohydrate (e.g. Creapure®) – the most thoroughly researched form of creatine. In addition, the chosen preparation should avoid unnecessary additives, because supplements, especially those containing creatine, often contain a number of additives.
Whether in the morning or evening, creatine can basically be taken anytime. However, many athletes swear by taking it shortly before (< 1 h) or shortly after training, as the cells are supplied with creatine particularly quickly due to the increased blood flow. Even on non-training days, creatine should be supplemented, as the supplement is particularly effective when taken without interruptions.
Whether you train or not, creatine is most effective when taken daily. It is best taken in combination with sugary drinks or carbohydrate-rich meals, because creatine is absorbed more quickly into the muscle cells in the presence of insulin.
While warm fluids improve the dissolving behaviour of creatine powders, excessive consumption of caffeine should be avoided. Studies suggest that there may be an interaction between caffeine and creatine that could impair explosive power development and sprint performance.
Not only can creatine and protein be taken together without any problems, but taking them together can even be an effective strategy for building muscle mass, improving athletic performance and shortening the recovery period after intensive training.
Combining BCAA and creatine is another clever move – especially if you are taking them to achieve a more muscular appearance. While the branched-chain amino acids (BCAA) specifically support muscle building, creatine not only helps to provide the necessary energy, it also makes our muscles appear fuller due to the increased water retention.
The time at which creatine takes effect varies from person to person. In general, effects can be felt a few days after the depots are filled.
However, in the case of creatine, there are also non-responders – people who do not respond at all to the intake. One possible explanation for this may be that the depots were already well stocked without targeted creatine intake. The level of training also seems to play a role in the success of creatine supplementation.Who should take creatine?
For a long time, creatine was trapped in the sports and fitness sector. Completely wrongly, as many new studies show. Not only can the vital substance boost performance during short, high-intensity and intermittent exertions – it can also help non-athletes to achieve more physical and mental strength under certain circumstances. A targeted intake is particularly worth considering for vegans, vegetarians, middle-aged women and older people. In addition, studies show that creatine could also alleviate certain symptoms of depression.
Conclusion: creatine provides energy when muscles and the brain are slowly running out of steam. Although the energy bundle can be produced by our body itself, under certain circumstances – in sports, with increasing age or a plant-based diet – an optimised creatine intake can help us to draw on unlimited resources more easily, both physically and mentally.
No, creatine has no effect on the contraceptive pill.
Creatine can be taken in both your suitcase and hand luggage within the EU (be careful with liquid preparations!). However, this only applies to quantities for personal use – so you should not take more creatine with you than you will actually need on holiday.
Like other foods and dietary supplements, creatine supplements have a best-before date, but they can be used without concern before this date expires. However, creatine monohydrate powders can usually be stored for years if they are stored in a cool, dry place.
Among athletes, creatine supplementation has been widespread and well documented for years – especially in disciplines that require maximum strength, speed and strength endurance. But even for non-athletes, a targeted creatine intake can be useful for optimising creatine stores. These include vegans, vegetarians, middle-aged women and older people.
Creatine is a carbon-nitrogen compound that is formed in our body from the three amino acids glycine, arginine and methionine.
Creatine increases the water content in muscle cells. If you take creatine with the intention of putting on weight, you may gain 1-2 kg. However, when you stop taking creatine, the weight you have gained will disappear within a few weeks.
Yes, creatine also helps non-athletes to better develop their mental and physical potential. It is particularly worth considering taking creatine for vegans and vegetarians, middle-aged women and older people.
No, creatine is not on the list of banned substances.
Study results suggest that higher amounts of caffeine (between 5-7 mg of caffeine per body weight = about 4 filter coffees for a person weighing 70 kg) could possibly impair the effect of creatine.
References:
Roschel, H. et al. 2021. Creatine Supplementation and Brain Health. Nutrients. 2021 Feb 10;13(2):586. doi: 10.3390/nu13020586. https://pubmed.ncbi.nlm.nih.gov/33578876/
Smith-Ryan, A. et al. 2021. Creatine Supplementation in Women's Health: A Lifespan Perspective. Nutrients. 2021 Mar 8;13(3):877. doi: 10.3390/nu13030877. https://pubmed.ncbi.nlm.nih.gov/33800439/
Forbes, S.C. et al. 2023. Creatine supplementation and endurance performance: surges and sprints to win the race. J Int Soc Sports Nutr. 2023 Dec;20(1):2204071. doi: 10.1080/15502783.2023.2204071. https://pubmed.ncbi.nlm.nih.gov/37096381/
Prokopidis, K. et al. 2023. Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023 Mar 10;81(4):416-427. doi: 10.1093/nutrit/nuac064.
Almeida, D. et al. 2020. Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study. J Sports Med Phys Fitness. 2020 Jul;60(7):1034-1039. doi: 10.23736/S0022-4707.20.10437-7. https://pubmed.ncbi.nlm.nih.gov/32597619/
Mielgo-Ayuso, J. et al. 2019. Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis. Nutrients. 2019 Mar 31;11(4):757. doi: 10.3390/nu11040757. https://pubmed.ncbi.nlm.nih.gov/30935142/
Wax, B. et al. 2021. Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients. 2021 Jun 2;13(6):1915. doi: 10.3390/nu13061915. https://pubmed.ncbi.nlm.nih.gov/34199588/
Avgerinos, K.I. et al. 2018. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018 Jul 15:108:166-173. doi: 10.1016/j.exger.2018.04.013. Epub 2018 Apr 25. https://pubmed.ncbi.nlm.nih.gov/29704637/
Kreider, R.B., Stout, J.R. 2021. Creatine in Health and Disease. Nutrients. 2021 Jan 29;13(2):447. doi: 10.3390/nu13020447. https://pubmed.ncbi.nlm.nih.gov/33572884/
Juneja, K. et al. 2024. Creatine Supplementation in Depression: A Review of Mechanisms, Efficacy, Clinical Outcomes, and Future Directions. Cureus. 2024 Oct 16;16(10):e71638. doi: 10.7759/cureus.71638. eCollection 2024 Oct. https://pubmed.ncbi.nlm.nih.gov/39553021/
Aguiar, A.F. et al. 2013. Long-term creatine supplementation improves muscular performance during resistance training in older women. Eur J Appl Physiol. 2013 Apr;113(4):987-96. doi: 10.1007/s00421-012-2514-6. Epub 2012 Oct 7. https://pubmed.ncbi.nlm.nih.gov/23053133/
McMorris, T. et al. 2007. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. doi: 10.1080/13825580600788100. https://pubmed.ncbi.nlm.nih.gov/17828627/
Wallimann, T. 2014. Positive Wirkung von Kreatin im Alter und für Rehabilitation. Schweizer Zeitschrift für Ernährungsmedizin 1/14. https://www.rosenfluh.ch/media/ernaehrungsmedizin/2014/01/Lesermeinung__Positive_Wirkung_von_Kreatin_im_Alter_und_fur_die_Rehabilitation.pdf
Klopstock, T. et al. 2011. Creatine in mouse models of neurodegeneration and aging. Amino Acids. 2011 May;40(5):1297-303. doi: 10.1007/s00726-011-0850-1. Epub 2011 Mar 10. https://pubmed.ncbi.nlm.nih.gov/21390530/
Wallimann, T. 2008. Kreatin – warum, wann und für wen? Schweizer Zeitschrift für Ernährungsmedizin 5/08. https://www.rosenfluh.ch/media/ernaehrungsmedizin/2008/05/Kreatin-warum-wann-und-fuer-wen.pdf
McMorris, T., et al. 2007. Creatine supplementation and cognitive performance in elderly individuals. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2007 Sep;14(5):517-28. doi: 10.1080/13825580600788100. https://pubmed.ncbi.nlm.nih.gov/17828627/
Brudnak, M.A. 2004. Creatine: are the benefits worth the risk? Toxicol Lett. 2004 Apr 15;150(1):123-30. doi: 10.1016/j.toxlet.2004.01.013. https://pubmed.ncbi.nlm.nih.gov/15068829/
Kim, H.J., et al. 2011. Studies on the safety of creatine supplementation. Amino Acids. 2011 May;40(5):1409-18. doi: 10.1007/s00726-011-0878-2. Epub 2011 Mar 12. https://pubmed.ncbi.nlm.nih.gov/21399917/
Wallimann, T. 2009. Kreatin in der Allgemeinmedizin. Ars Medici Dossier VII+VIII, 2009. https://www.rosenfluh.ch/media/arsmedici-dossier/2009/07-08/Kreatin_in_der_Allgemeinmedizin.pdf
